Anti-Epileptic Drugs Increase Risk of Dementia

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The use of antiepileptic drugs is associated with an increased risk of Alzheimer’s disease and Dementia, according to a new study. Continuous use of anti-epileptic drugs for a period exceeding one year was associated with a 15 percent increased risk of Alzheimer’s disease in the Finnish dataset, and with a 30 percent increased risk of Dementia in the German dataset.

Some anti-epileptic drugs are known to impair cognitive function, which refers to all different aspects of information processing. When the researchers compared different anti-epileptic drugs, they found that the risk of Alzheimer’s disease and Dementia was specifically associated with drugs that impair cognitive function. These drugs were associated with a 20 percent increased risk of Alzheimer’s disease and with a 60 percent increased risk of dementia.

The researchers also found that the higher the dose of a drug that impairs cognitive function, the higher the risk of Dementia. However, other antiepileptic drugs, i.e. those which do not impair cognitive processing, were not associated with the risk.

“More research should be conducted into the long-term cognitive effects of these drugs, especially among older people,” Senior Researcher Heidi Taipale from the University of Eastern Finland says.

Besides for epilepsy, antiepileptic drugs are used in the treatment of neuropathic pain, bipolar disorder and generalised anxiety disorder. This new study is the largest research on the topic so far, and the first to investigate the association in terms of regularity of use, dose and comparing the risk between antiepileptic drugs with and without cognitive-impairing effects. The results were published in the Journal of the American Geriatrics Society.

Source: Science Daily

By | 2018-04-10T13:51:15+00:00 April 10th, 2018|Medication, Research|0 Comments

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The Jura Care Research Team is dedicated to bringing insightful and valuable information to the public, within the domain of Alzheimer's and other forms of Dementia. Content published online is for informational purposes and does not necessarily reflect the view point or perspective of the Jura Care Village. The Jura Care Team does not claim any ownership of the content it publishes online.

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